South Francisco is located in the western part of the state of California and a city in San Mateo County. It sits along the southern region at the base of San Bruno Mountain, which is in the south part of San Francisco. The area where the present-day South San Francisco stands used to be a part of Rancho Burburi, a Mexican land grant that was granted and designated in 1835. The majority of the land area was purchased by Henry Miller and Charles Lux, who then built a large estate on the site. It was later in 1890 when it was purchased by Peter Iler and was then laid out in the same year. The city was developed to become highly industrialized, wherein meatpacking, steel, and other metal fabrication and manufacturing plants were established. Over the years, South San Francisco became a center of the biotechnology industry, and at the same time boasts its attractive residential section in the city that has magnificent views of the San Francisco Bay.
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