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Located on the eastern side of Massachusetts in Middlesex County, Cambridge is situated in the northern part of the Charles River, which is geographically opposite to Boston. The city's early development and progress have been slow. The city has first set up a printing press and became a forerunner in the modern publishing and printing industry, and wherein the first books were printed. With the completion of the subway connections to the city of Boston, it was then that Cambridge experienced rapid growth in its industrial expansion. During the late 20th century, the manufacturing industry experienced a decline and was later replaced by firms and corporations that are developing high-technology and biotechnology. Industrial and scientific research has stimulated the presence of Harvard University and the Massachusetts Institute of Technology, and these institutions became Cambridge's largest employers.